Comparison of Hematologic and Febrile Response to Endotoxin in Man.

Comparison of Heinatologic and Febrile Response to Endotoxin in Man

By SHELDON M. WOLFF, MELVIN RUBENSTEIN, JOHN H. MULHOLLAND AND DAVID W. ALLING T HE PROFOUND HEMATOLOGIC alterations evoked in experimental animals following endotoxin administration have been considered to play a major role in the pathogenesis of some of the biologic effects produced by these lipopolysaccharides. Marked leukopenia, primarily granulocytopenia, and subsequent granulocytosis as w...

Observations on the pyrogenic response and its application to the bioassay of endotoxin.

Endotoxins prepared from gram-negative bacteria produce a wide variety of physiological reactions when administered to man and experimental animals. The intravenous injection of microgram quantities of these lipopolysaccharides into the appropriate host is followed by fever, leukopenia, thrombocytopenia, hyperglycemia, and irreversible shock. In addition, endotoxins are capable of producing the...

Pharmacokinetics and dosage regimen of cefpirome in febrile cross-bred calves

The pharmacokinetics of cefpirome after a single intravenous injection of 10 mg.kg -1 was studied in febrile cross-bred calves. E. coli endotoxin was administered intravenously to induce fever in calves. Blood samples were collected at different time intervals and cefpirome levels were estimated by using microbiological assay technique. Based on the plasma drug levels, the pharmacokinetic pa...

Author's response to reviews Title: Clinical Characteristics and Antimicrobial Susceptibilities of viridans Streptococcal Bacteremia during Febrile Neutropenia in Patients with Hematologic Malignancies: A Comparison between Adults and Children Authors:

Endotoxin Fever in Granulocytopenic Animals

The febrile response to bacterial endotoxin was measured in rabbits made leukopenic with nitrogen mustard. A striking increase in susceptibility to the lethal effects of endotoxin occurred in severely leukopenic animals. Animals without circulating granulocytes, or with only basophils, developed no significant fever after endotoxin injection. Animals with circulating granulocytes other than bas...